Article
Development of a genetically tailored implantation hepatocellular carcinoma model in Oncopigs by somatic cell CRISPR editing.
Disease models & mechanisms - 1 Jan 2025
Elkhadragy Lobna, Carlino Maximillian J, Jordan Luke R, Pennix Thomas, Ismail Nahed, Guzman Grace, Samuelson Jonathan P, Schook Lawrence B, Schachtschneider Kyle M, Gaba Ron C
Abstract excerpt
Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis, necessitating preclinical models for evaluating novel therapies. Large-animal models are particularly valuable for assessing locoregional therapies, which are widely employed across HCC stages. This study aimed to develop a large-animal HCC model with tailored tumor mutations. The Oncopig, a genetically engineered pig with inducible...
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