Article
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.
Communications biology - 28 Dec 2022
Sugawara Sho, Okada Ryo, Loo Tze Mun, Tanaka Hisamichi, Miyata Kenichi, Chiba Masatomo, Kawasaki Hiroko, Katoh Kaoru, Kaji Shizuo, Maezawa Yoshiro, Yokote Koutaro, Nakayama Mizuho, Oshima Masanobu, Nagao Koji, Obuse Chikashi, Nagayama Satoshi, Takubo Keiyo, Nakanishi Akira, Kanemaki Masato T, Hara Eiji, Takahashi Akiko
Abstract excerpt
Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated secretory phenotype (SASP). SASP is mediated by the activation of cytoplasmic nucleic acid sensors. However, the molecular mechanism underlying the accumulation of nucleotide ligands in senescent cells is unclear. In this study, we revealed that the expression of...
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