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Article

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease.

Acta neuropathologica communications - 6 Jul 2013

Stutzbach Lauren D, Xie Sharon X, Naj Adam C, Albin Roger, Gilman Sid, Lee Virginia M Y, Trojanowski John Q, Devlin Bernie, Schellenberg Gerard D

Abstract excerpt

BACKGROUND: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. A genome-wide association study identified EIF2AK3 as a risk factor for PSP. EIF2AK3 encodes PERK, part of the endoplasmic reticulum's (ER) unfolded protein response (UPR). PERK...

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Identifiers

PMID: 24252572
DOI: 10.1186/2051-5960-1-31
PMCID: PMC3893579

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