Article

Ethnic variation and structure-function analysis of tauopathy-associated<i>PERK</i>alleles

2024-03-04

Abstract excerpt

<h4>SUMMARY</h4> EIF2AK3, also known as PERK, plays a pivotal role in cellular proteostasis, orchestrating the Unfolded Protein Response (UPR) and Integrated Stress Response (ISR) pathways. In addition to its central position in intracellular stress regulation, human GWAS identify EIF2AK3 as a risk factor in tauopathies, neurodegenerative diseases caused by aberrant tau protein accumulation. Guided by these genomi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40579d35-b843-5814-ba63-2408eb3b89d3
DOI: 10.1101/2024.03.03.24303689

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ethnic variation and structure-function analysis of tauopathy-associated<i>PERK</i>allelesDOI 10.1101/2024.03.03.24303689Read

Neurodegeneration Risk Factor, <i>EIF2AK3</i> ( <i>PERK</i> ), Influences Tau Protein AggregationSemantic proximity Read

Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.Semantic proximity Read

Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.Semantic proximity Read

A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human PhosphoproteomesSemantic proximity Read

PhosSNP for systematic analysis of genetic polymorphisms that influence protein phosphorylation.Semantic proximity Read

A panoramic perspective on human phosphositesSemantic proximity Read

Mapping Cryptic Phosphorylation Sites in the Human ProteomeSemantic proximity Read

Mapping Cryptic Phosphorylation Sites in the Human ProteomeSemantic proximity Read

A global atlas of substrate specificities for the human serine/threonine kinomeSemantic proximity Read

Scop3P in 2026: an expanded proteomics-informed resource contextualizing phosphorylation sites through sequence, structure, mutation, and experimental provenanceSemantic proximity Read

The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structuresSemantic proximity Read

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum StressSemantic proximity Read