Article
Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells.
Aging cell - 1 Jun 2022
You Yang, Hersh Samuel W, Aslebagh Roshanak, Shaffer Scott A, Ikezu Seiko, Mez Jesse, Lunetta Kathryn L, Logue Mark W, Farrer Lindsay A, Ikezu Tsuneya
Abstract excerpt
Alzheimer's disease (AD) is a pervasive neurodegeneration disease with high heritability. In this study, we employed CRISPR-Cas9-engineered technology to investigate the effects of a rare mutation (rs144662445) in the A kinase anchoring protein 9 (AKAP9) gene, which is associated with AD in African Americans (AA), on tau pathology and the tau interactome in SH-SY5Y P301L neuron-like cells. The mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.