Article

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

2018-09-17

Abstract excerpt

<h4>ABSTRACT</h4> The PERK arm of the unfolded protein response (UPR) regulates cellular proteostasis and survival in response to endoplasmic reticulum (ER) stress. However, the impact of PERK signaling on extracellular proteostasis is poorly understood. We define how PERK signaling influences extracellular proteostasis during ER stress using a conformational reporter of the secreted amyloidogenic protein transth...

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Literature Corpus work: 4262fe81-bc36-5078-9cc2-3f54891ac8ba
DOI: 10.1101/419564

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