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Article

Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer.

Cells - 13 Dec 2022

Pardella Elisa, Pranzini Erica, Nesi Ilaria, Parri Matteo, Spatafora Pietro, Torre Eugenio, Muccilli Angela, Castiglione Francesca, Fambrini Massimiliano, Sorbi Flavia, Cirri Paolo, Caselli Anna, Puhr Martin, Klocker Helmut, Serni Sergio, Raugei Giovanni, Magherini Francesca, Taddei Maria Letizia

Abstract excerpt

Cancer progression is supported by the cross-talk between tumor cells and the surrounding stroma. In this context, senescent cells in the tumor microenvironment contribute to the development of a pro-inflammatory milieu and the acquisition of aggressive traits by cancer cells. Anticancer treatments induce cellular senescence (therapy-induced senescence, TIS) in both tumor and non-cancerous cells, contributing to...

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Identifiers

PMID: 36552790
DOI: 10.3390/cells11244026
PMCID: PMC9776582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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