Article
Nuclear deformation and expression change of cartilaginous genes during in vitro expansion of chondrocytes.
Biochemical and biophysical research communications - 3 Oct 2008
Hoshiba Takashi, Yamada Tomoe, Lu Hongxu, Kawazoe Naoki, Tateishi Tetsuya, Chen Guoping
Abstract excerpt
Cartilaginous gene expression decreased when chondrocytes were expanded on cell-culture plates. Understanding the dedifferentiation mechanism may provide valuable insight into cartilage tissue engineering. Here, we demonstrated the relationship between the nuclear shape and gene expression during in vitro expansion culture of chondrocytes. Specifically, the projected nuclear area increased and cartilaginous gene...
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