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Synaptic resilience is associated with maintained cognition during ageing

22 Dec 2022

Abstract excerpt

INTRODUCTION: It remains unclear why age increases risk of Alzheimer's disease and why some people experience age-related cognitive decline in the absence of dementia. Here we test the hypothesis that resilience to molecular changes in synapses contribute to healthy cognitive ageing. METHODS: We examined post-mortem brain tissue from people in mid-life (n = 15), healthy ageing with either maintained cognition (n...

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PMID: 36547260
DOI: 10.1002/alz.12894

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