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Article

Interfering with nucleotide excision by the coronavirus 3′-to-5′ exoribonuclease

27 Nov 2022

Abstract excerpt

Some of the most efficacious antiviral therapeutics are ribonucleos(t)ide analogs. The presence of a 3'-to-5' proofreading exoribonuclease (ExoN) in coronaviruses diminishes the potency of many ribonucleotide analogs. The ability to interfere with ExoN activity will create new possibilities for control of SARS-CoV-2 infection. ExoN is formed by a 1:1 complex of nsp14 and nsp10 proteins. We have purified and...

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PMID: 36546762
DOI: 10.1093/nar/gkac1177

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