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Article

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites.

Antiviral research - 1 Jun 2020

Shannon Ashleigh, Le Nhung Thi-Tuyet, Selisko Barbara, Eydoux Cecilia, Alvarez Karine, Guillemot Jean-Claude, Decroly Etienne, Peersen Olve, Ferron Francois, Canard Bruno

Abstract excerpt

The rapid global emergence of SARS-CoV-2 has been the cause of significant health concern, highlighting the immediate need for antivirals. Viral RNA-dependent RNA polymerases (RdRp) play essential roles in viral RNA synthesis, and thus remains the target of choice for the prophylactic or curative treatment of several viral diseases, due to high sequence and structural conservation. To date, the most promising...

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Identifiers

PMID: 32283108
DOI: 10.1016/j.antiviral.2020.104793
PMCID: PMC7151495

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