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Article

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.

PLoS pathogens - 1 Aug 2013

Smith Everett Clinton, Blanc Hervé, Surdel Matthew C, Vignuzzi Marco, Denison Mark R

Abstract excerpt

No therapeutics or vaccines currently exist for human coronaviruses (HCoVs). The Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) epidemic in 2002-2003, and the recent emergence of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in April 2012, emphasize the high probability of future zoonotic HCoV emergence causing severe and lethal human disease. Additionally, the resistance of...

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Identifiers

PMID: 23966862
DOI: 10.1371/journal.ppat.1003565
PMCID: PMC3744431

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