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The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target

3 Dec 2021

Abstract excerpt

The risk of zoonotic coronavirus spillover into the human population, as highlighted by the SARS-CoV-2 pandemic, demands the development of pan-coronavirus antivirals. The efficacy of existing antiviral ribonucleoside/ribonucleotide analogs, such as remdesivir, is decreased by the viral proofreading exonuclease NSP14-NSP10 complex. Here, using a novel assay and in silico modeling and screening, we identified...

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PMID: 34862481
DOI: 10.1038/s41418-021-00900-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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