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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

7 Aug 2019

Abstract excerpt

Among RNA viruses, the order Nidovirales stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps). One of the postulated drivers of the expansion of nidovirus genomes is the presence of a proofreading 3’-to-5’ exoribonuclease (ExoN) belonging to the DEDDh family. ExoN may enhance...

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PMID: 31440227
DOI: 10.3389/fmicb.2019.01813

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