Article
Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice.
eLife - 21 Dec 2022
Xie Rong, Yi Dan, Zeng Daofu, Jie Qiang, Kang Qinglin, Zhang Zeng, Zhang Zhenlin, Xiao Guozhi, Chen Lin, Tong Liping, Chen Di
Abstract excerpt
Axin1 is a key regulator of canonical Wnt signaling pathway. Roles of Axin1 in skeletal development and in disease occurrence have not been fully defined. Here, we report that Axin1 is essential for lower limb development. Specific deletion of Axin1 in limb mesenchymal cells leads to fibular hemimelia (FH)-like phenotype, associated with tarsal coalition. Further studies demonstrate that FH disease is associated...
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