Article
Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.
PloS one - 1 Jan 2012
Suzuki Kentaro, Adachi Yasuha, Numata Tomokazu, Nakada Shoko, Yanagita Motoko, Nakagata Naomi, Evans Sylvia M, Graf Daniel, Economides Aris, Haraguchi Ryuma, Moon Anne M, Yamada Gen
Abstract excerpt
Sirenomelia, also known as mermaid syndrome, is a developmental malformation of the caudal body characterized by leg fusion and associated anomalies of pelvic/urogenital organs including bladder, kidney, rectum and external genitalia. Most affected infants are stillborn, and the few born alive rarely survive beyond the neonatal period. Despite the many clinical studies of sirenomelia in humans, little is known...
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