Article
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response.
Journal of neuroinflammation - 20 Dec 2022
Manet Caroline, Mansuroglu Zeyni, Conquet Laurine, Bortolin Violaine, Comptdaer Thomas, Segrt Helena, Bourdon Marie, Menidjel Reyene, Stadler Nicolas, Tian Guanfang, Herit Floriane, Niedergang Florence, Souès Sylvie, Buée Luc, Galas Marie-Christine, Montagutelli Xavier, Bonnefoy Eliette
Abstract excerpt
BACKGROUND: Zika virus (ZIKV) infection at postnatal or adult age can lead to neurological disorders associated with cognitive defects. Yet, how mature neurons respond to ZIKV remains substantially unexplored. METHODS: The impact of ZIKV infection on mature neurons and microglia was analyzed at the molecular and cellular levels, in vitro using immunocompetent primary cultured neurons and microglia, and in vivo in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.