Article

Type I interferons govern Zika virus resistance of human macrophages and microglia

2022-03-11

Abstract excerpt

The role of the human type I interferon (IFN-I) system in restricting Zika virus (ZIKV) is uncertain. Here, genetic and pharmacological ablation of IFN-I signalling enhanced ZIKV replication and cytopathicity in macrophages and microglia, key cells in ZIKV transmission and pathogenesis. Thus, despite the extensive IFN-I countermeasures employed by ZIKV, IFN-I dictates the outcome of infection in macrophages. Thera...

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Literature Corpus work: 4b94b829-d78a-5fcd-aaf6-4c99d66e3f17
DOI: 10.1101/2022.03.09.483671

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