A common missense variant rs874881 of PADI4 gene and rheumatoid arthritis: Genetic association study and in-silico analysis.

doi:10.1016/j.gene.2022.147123

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A common missense variant rs874881 of PADI4 gene and rheumatoid arthritis: Genetic association study and in-silico analysis.

Gene - 20 Feb 2023

Bashir Mutshaba, Mateen Wajeeha, Khurshid Sadia, Mehmood Malik Javaid, Agha Zehra, Khan Fariha, Ajmal Muhammad, Ali Syeda Hafiza Benish

Abstract excerpt

The peptidylarginine-deiminase 4 (PADI4) is involved in the post-translational catalytic conversion of arginine into citrulline. The autoantibodies including anti-citrullinated protein antibodies (ACPAs) produced in response to hypercitrullinated proteins are a hallmark of rheumatoid arthritis (RA) autoimmunity. Therefore, the role of a missense variant rs874881 (Gly112Ala) of PADI4 in RA susceptibility was...

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PMID: 36535460
DOI: 10.1016/j.gene.2022.147123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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