Article
Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.
Arthritis research & therapy - 19 Nov 2012
Too Chun Lai, Murad Shahnaz, Dhaliwal Jasbir Singh, Larsson Per, Jiang Xia, Ding Bo, Alfredsson Lars, Klareskog Lars, Padyukov Leonid
Abstract excerpt
INTRODUCTION: The majority of our knowledge regarding disease-related mechanisms of uncontrolled citrullination and anti-citrullinated protein antibody development in rheumatoid arthritis (RA) was investigated in Caucasian populations. However, peptidylarginine deiminase (PADI) type 4 gene polymorphisms are associated with RA in East Asian populations and weak or no association was found in Caucasian populations....
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