Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PADI2 is significantly associated with rheumatoid arthritis.

PloS one - 1 Jan 2013

Chang Xiaotian, Xia Yifang, Pan Jihong, Meng Qingsong, Zhao Yan, Yan Xinfeng

Abstract excerpt

Citrullination, a posttranslational modification of peptidyl arginine to citrulline, plays an essential role in rheumatoid arthritis (RA). Citrullination is catalyzed by a group of peptidylarginine deiminases (PADs) including PADI 1, 2, 3, 4 and 6. Many studies have indicated that the gene encoding PADI4 is a factor in susceptibility to RA. Some studies have detected PADI2 expression in RA synovial tissues,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Arthritis, Rheumatoid
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genotyping Techniques

Share to Hydrolases

Share to Protein-Arginine Deiminases

Share to Synovial Membrane

Source

Open in PubMed Open full text

Identifiers

PMID: 24339914
DOI: 10.1371/journal.pone.0081259
PMCID: PMC3855321

Genes

PADI2
PADI4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PADI2 is significantly associated with rheumatoid arthritis.PMID 24339914Read ↗

Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients.Semantic proximity Read ↗

PADI2 Polymorphisms Are Significantly Associated With Rheumatoid Arthritis, Autoantibodies Serologic Status and Joint Damage in Women from Southern Mexico.Semantic proximity Read ↗

PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets.Semantic proximity Read ↗

Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene.Semantic proximity Read ↗

A common missense variant rs874881 of PADI4 gene and rheumatoid arthritis: Genetic association study and in-silico analysis.Semantic proximity Read ↗

PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritisSemantic proximity Read ↗

Citrullination by peptidylarginine deiminase in rheumatoid arthritis.Semantic proximity Read ↗

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.Semantic proximity Read ↗

Single-Nucleotide Variants in PADI2 and PADI4 and Ancestry Informative Markers in Interstitial Lung Disease and Rheumatoid Arthritis among a Mexican Mestizo PopulationSemantic proximity Read ↗

Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.Semantic proximity Read ↗

PAD, a growing family of citrullinating enzymes: genes, features and involvement in diseaseSemantic proximity Read ↗

From genetics to functional insights into rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.