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Article

Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors.

Leukemia - 1 Feb 2023

Braun Theodore P, Estabrook Joseph, Schonrock Zachary, Curtiss Brittany M, Darmusey Lucie, Macaraeg Jommel, Enright Trevor, Coblentz Cody, Callahan Rowan, Yashar William, Taherinasab Akram, Mohammed Hisham, Coleman Daniel J, Druker Brian J, Demir Emek, Lusardi Theresa A, Maxson Julia E

Abstract excerpt

Mutations in the gene Additional Sex-Combs Like 1 (ASXL1) are recurrent in myeloid malignancies as well as the pre-malignant condition clonal hematopoiesis, where they are universally associated with poor prognosis. However, the role of ASXL1 in myeloid lineage maturation is incompletely described. To define the role of ASXL1 in myelopoiesis, we employed single cell RNA sequencing and a murine model of...

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Identifiers

PMID: 36526735
DOI: 10.1038/s41375-022-01792-x
PMCID: PMC9899319

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