Article
Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors.
Scientific reports - 13 Dec 2022
Bongers B J, Gorostiola González M, Wang X, van Vlijmen H W T, Jespers W, Gutiérrez-de-Terán H, Ye K, IJzerman A P, Heitman L H, van Westen G J P
Abstract excerpt
G Protein-coupled receptors (GPCRs) are the most frequently exploited drug target family, moreover they are often found mutated in cancer. Here we used a dataset of mutations found in patient samples derived from the Genomic Data Commons and compared it to the natural human variance as exemplified by data from the 1000 genomes project. We explored cancer-related mutation patterns in all GPCR classes combined and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.