Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

Abstract excerpt

Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or repression of key cancer-relevant pathways. However, as many pathways contain multiple members of the same gene family, individual mutations might be overlooked, as each family member would necessarily have a lower mutation frequency and thus not identified as significant in any...

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