Diverse somatic mutation patterns and pathway alterations in human cancers.

doi:10.1038/nature09208

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Article

Diverse somatic mutation patterns and pathway alterations in human cancers.

Nature - 12 Aug 2010

Kan Zhengyan, Jaiswal Bijay S, Stinson Jeremy, Janakiraman Vasantharajan, Bhatt Deepali, Stern Howard M, Yue Peng, Haverty Peter M, Bourgon Richard, Zheng Jianbiao, Moorhead Martin, Chaudhuri Subhra, Tomsho Lynn P, Peters Brock A, Pujara Kanan, Cordes Shaun, Davis David P, Carlton Victoria E H, Yuan Wenlin, Li Li, Wang Weiru, Eigenbrot Charles, Kaminker Joshua S, Eberhard David A, Waring Paul, Schuster Stephan C, Modrusan Zora, Zhang Zemin, Stokoe David, de Sauvage Frederic J, Faham Malek, Seshagiri Somasekar

Abstract excerpt

The systematic characterization of somatic mutations in cancer genomes is essential for understanding the disease and for developing targeted therapeutics. Here we report the identification of 2,576 somatic mutations across approximately 1,800 megabases of DNA representing 1,507 coding genes from...

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PMID: 20668451
DOI: 10.1038/nature09208

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APLNR
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20668451-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

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