Article
Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors.
Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 2021
Huh Eunna, Gallion Jonathan, Agosto Melina A, Wright Sara J, Wensel Theodore G, Lichtarge Olivier
Abstract excerpt
G protein-coupled receptors (GPCRs) are the largest family of human proteins. They have a common structure and, signaling through a much smaller set of G proteins, arrestins, and effectors, activate downstream pathways that often modulate hallmark mechanisms of cancer. Because there are many more GPCRs than effectors, mutations in different receptors could perturb signaling similarly so as to favor a tumor. We...
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