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Article

Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets.

Biochimica et biophysica acta - 1 Apr 2007

Insel Paul A, Tang Chih-Min, Hahntow Ines, Michel Martin C

Abstract excerpt

By virtue of their large number, widespread distribution and important roles in cell physiology and biochemistry, G-protein-coupled receptors (GPCR) play multiple important roles in clinical medicine. Here, we focus on 3 areas that subsume much of the recent work in this aspect of GPCR biology: (1) monogenic diseases of GPCR; (2) genetic variants of GPCR; and (3) clinically useful pharmacological agonists and...

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Identifiers

PMID: 17081496
DOI: 10.1016/j.bbamem.2006.09.029
PMCID: PMC2169201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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