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Article

LRRC8A critically regulates myofibroblast phenotypes and fibrotic remodeling following myocardial infarction.

Theranostics - 1 Jan 2022

Chen Xiyao, Zhang Fuyang, Hu Guangyu, Li Xing, Wang Lin, Li Congye, Huo Cong, Xu Rong, Hou Liming, Wang Ning, Wang Xiaoming

Abstract excerpt

Rationale: The transformation of fibroblasts into activated myofibroblasts is a critical step that results in cardiac fibrosis upon myocardial infarction (MI). Leucine-rich repeat-containing protein-8A (LRRC8A) is a multi-functional protein involved in cell survival, growth, and proliferation, whereas its role in regulating myofibroblast phenotypes and myocardial fibrosis remains unknown. Methods: Conditional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35966575
DOI: 10.7150/thno.75200
PMCID: PMC9373806

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