Article
Macrophage Polarization as a Therapeutic Target in Myocardial Infarction.
Current drug targets - 1 Jan 2018
Cheng Yuanyuan, Rong Jianhui
Abstract excerpt
BACKGROUND: Myocardial infarction is characterized by the interruption of blood flow through the heart, directly causing mortality and disability worldwide. Cardiac macrophages exhibit distinct phenotypes (e.g., M1 or M2) and functions (e.g., proinflammatory or anti-inflammatory) in response to the alterations of myocardial microenvironment, and subsequently exacerbate or resolve inflammation in the infarcted...
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