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Article

HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype.

Basic research in cardiology - 23 Apr 2021

Li Yanjiao, Dong Min, Wang Qing, Kumar Santosh, Zhang Rui, Cheng Wanwen, Xiang Jiaqing, Wang Gang, Ouyang Kunfu, Zhou Ruxing, Xie Yaohong, Lu Yishen, Yi Jing, Duan Haixia, Liu Jie

Abstract excerpt

Appropriately manipulating macrophage M1/M2 phenotypic transition is a promising therapeutic strategy for tissue repair after myocardial infarction (MI). Here we showed that gene ablation of hypoxia-induced mitogenic factor (HIMF) in mice (Himf-/- and HIMFflox/flox;Lyz2-Cre) attenuated M1 macrophage-dominated inflammatory response and promoted M2 macrophage accumulation in infarcted hearts. This in turn reduced...

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Identifiers

PMID: 33893593
DOI: 10.1007/s00395-021-00867-7
PMCID: PMC8064941

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