Article
Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2023
Lin Kehuan, McCormick Natalie, Yokose Chio, Joshi Amit D, Lu Na, Curhan Gary C, Merriman Tony R, Saag Kenneth G, Ridker Paul M, Buring Julie E, Chasman Daniel I, Hu Frank B, Choi Hyon K
Abstract excerpt
OBJECTIVE: To examine whether the cross-sectional gene-diet interaction for prevalent hyperuricemia among women translates prospectively to risk of incident female gout. METHODS: We analyzed the interaction between genetic predisposition and adherence to a healthy dietary pattern (i.e., Dietary Approaches to Stop Hypertension [DASH] score) on risk of incident female gout in 18,244 women from Nurses' Health Study...
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