Article
Lack of gene-diuretic interactions on the risk of incident gout: the Nurses' Health Study and Health Professionals Follow-up Study.
Annals of the rheumatic diseases - 1 Jul 2015
Bao Ying, Curhan Gary, Merriman Tony, Plenge Robert, Kraft Peter, Choi Hyon K
Abstract excerpt
BACKGROUND: Diuretic-induced gout might occur only among those with a genetic predisposition to hyperuricaemia, as suggested by a recent study with 108 self-reported gout cases. METHODS: We examined the role of urate genes on the risk of diuretic-induced incident gout in 6850 women from the Nurses' Health Study (NHS) and in 4223 men from the Health Professionals Follow-up Study (HPFS). Two published genetic risk...
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