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Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation

10 Feb 2022

Abstract excerpt

BACKGROUND: Sex hormone-binding globulin (SHBG), testosterone and oestradiol have been associated with many diseases in observational studies; however, the causality of associations remains unestablished. METHODS: A phenome-wide Mendelian randomization (MR) association study was performed to explore disease outcomes associated with genetically proxied circulating SHBG, testosterone and oestradiol levels by using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35218343
DOI: 10.1093/ije/dyac036

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