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Using human genetics to understand the epidemiological association between obesity, serum urate, and gout.

Rheumatology (Oxford, England) - 3 Oct 2023

Zhang Li, Zhang Wenqiang, Xiao Chenghan, Wu Xueyao, Cui Huijie, Yan Peijing, Yang Chao, Tang Mingshuang, Wang Yutong, Chen Lin, Liu Yunjie, Zou Yanqiu, Alfredsson Lars, Klareskog Lars, Yang Yanfang, Yao Yuqin, Li Jiayuan, Liu Zhenmi, Yang Chunxia, Jiang Xia, Zhang Ben

Abstract excerpt

OBJECTIVES: We aimed to clarify the genetic overlaps underlying obesity-related traits, serum urate, and gout. METHODS: We conducted a comprehensive genome-wide cross-trait analysis to identify genetic correlation, pleiotropic loci, and causal relationships between obesity (the exposure variable), gout (the primary outcome) and serum urate (the secondary outcome). Summary statistics were collected from the...

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PMID: 36734534
DOI: 10.1093/rheumatology/kead054

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