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Article

Additive and Multiplicative Interactions Between Genetic Risk Score and Family History and Lifestyle in Relation to Risk of Type 2 Diabetes.

American journal of epidemiology - 5 May 2020

Ding Ming, Ahmad Shafqat, Qi Lu, Hu Yang, Bhupathiraju Shilpa N, Guasch-Ferré Marta, Jensen Majken K, Chavarro Jorge E, Ridker Paul M, Willett Walter C, Chasman Daniel I, Hu Frank B, Kraft Peter

Abstract excerpt

We examined interactions between lifestyle factors and genetic risk of type 2 diabetes (T2D-GR), captured by genetic risk score (GRS) and family history (FH). Our initial study cohort included 20,524 European-ancestry participants, of whom 1,897 developed incident T2D, in the Nurses' Health Study (1984-2016), Nurses' Health Study II (1989-2016), and Health Professionals Follow-up Study (1986-2016). The analyses...

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PMID: 31647510
DOI: 10.1093/aje/kwz251
PMCID: PMC7462250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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