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Article

Assessing the Causal Relationships Between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2021

McCormick Natalie, O'Connor Mark J, Yokose Chio, Merriman Tony R, Mount David B, Leong Aaron, Choi Hyon K

Abstract excerpt

OBJECTIVE: Hyperuricemia is closely associated with insulin resistance syndrome (and its many cardiometabolic sequelae); however, whether they are causally related has long been debated. We undertook this study to investigate the potential causal nature and direction between insulin resistance and hyperuricemia, along with gout, by using bidirectional Mendelian randomization (MR) analyses. METHODS: We used...

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Identifiers

PMID: 33982892
DOI: 10.1002/art.41779
PMCID: PMC8568618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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