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Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis.

Microbiology spectrum - 14 Feb 2023

Jacques Laura C, Green Angharad E, Barton Thomas E, Baltazar Murielle, Aleksandrowicz Julia, Xu Rong, Trochu Erwan, Kadioglu Aras, Neill Daniel R

Abstract excerpt

The short generation time of many bacterial pathogens allows the accumulation of de novo mutations during routine culture procedures used for the preparation and propagation of bacterial stocks. Taking the major human pathogen Streptococcus pneumoniae as an example, we sought to determine the influence of standard laboratory handling of microbes on within-strain genetic diversity and explore how these changes...

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Identifiers

PMID: 36507681
DOI: 10.1128/spectrum.03103-22
PMCID: PMC9927508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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