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Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence

27 Aug 2007

Abstract excerpt

BACKGROUND: Streptococcus pneumoniae is the leading cause of community-acquired pneumonia. Previously, using comparative genomic analyses, 13 regions of genomic plasticity have been identified in the S. pneumoniae genome. These "Regions of Diversity" (RDs) accounted for half the genomic variation observed amongst all pneumococci tested, moreover, were determined to encode a variety of putative virulence factors....

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PMID: 17723151
DOI: 10.1186/1471-2180-7-80

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