Article
Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection.
PLoS genetics - 1 Jan 2013
Croucher Nicholas J, Mitchell Andrea M, Gould Katherine A, Inverarity Donald, Barquist Lars, Feltwell Theresa, Fookes Maria C, Harris Simon R, Dordel Janina, Salter Susannah J, Browall Sarah, Zemlickova Helena, Parkhill Julian, Normark Staffan, Henriques-Normark Birgitta, Hinds Jason, Mitchell Tim J, Bentley Stephen D
Abstract excerpt
Streptococcus pneumoniae of serotype 3 possess a mucoid capsule and cause disease associated with high mortality rates relative to other pneumococci. Phylogenetic analysis of a complete reference genome and 81 draft sequences from clonal complex 180, the predominant serotype 3 clone in much of the world, found most sampled isolates belonged to a clade affected by few diversifying recombinations. However, other...
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