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Relationship between polygenic risk scores and symptom dimensions of schizophrenia and schizotypy in multiplex families with schizophrenia

12 Dec 2022

Abstract excerpt

Background Psychotic disorders and schizotypal traits aggregate in the relatives of probands with schizophrenia. It is currently unclear how variability in symptom dimensions in schizophrenia probands and their relatives is associated with polygenic liability to psychiatric disorders. Aims To investigate whether polygenic risk scores (PRSs) can predict symptom dimensions in members of multiplex families with...

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PMID: 36503694
DOI: 10.1192/bjp.2022.179

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