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Article

Associations Between Schizophrenia Polygenic Liability, Symptom Dimensions, and Cognitive Ability in Schizophrenia.

JAMA psychiatry - 1 Oct 2021

Legge Sophie E, Cardno Alastair G, Allardyce Judith, Dennison Charlotte, Hubbard Leon, Pardiñas Antonio F, Richards Alexander, Rees Elliott, Di Florio Arianna, Escott-Price Valentina, Zammit Stanley, Holmans Peter, Owen Michael J, O'Donovan Michael C, Walters James T R

Abstract excerpt

Importance: Schizophrenia is a clinically heterogeneous disorder. It is currently unclear how variability in symptom dimensions and cognitive ability is associated with genetic liability for schizophrenia. Objective: To determine whether phenotypic dimensions within schizophrenia are associated with genetic liability to schizophrenia, other neuropsychiatric disorders, and intelligence. Design, Setting, and...

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Identifiers

PMID: 34347035
DOI: 10.1001/jamapsychiatry.2021.1961
PMCID: PMC8340009

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