Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bromodomain Protein BRD4-Mediated Mutant p53 Transcription Promotes TNBC Progression

2 Dec 2022

Abstract excerpt

is the most common mutated gene in human cancer. Mutant p53 protein loses its tumor-suppressor properties and gains oncogenic activity. Mutant p53 is a therapeutic target in a broad range of cancer types. However, how mutant p53 is epigenetically regulated during tumor progression remains elusive. In this study, we found that the upregulation of mutant p53 is mediated by bromodomain protein BRD4 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Myeloma Research and Treatments
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36499487
DOI: 10.3390/ijms232315163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bromodomain Protein BRD4-Mediated Mutant p53 Transcription Promotes TNBC ProgressionPMID 36499487Read ↗

Post-Translational Modifications of BRD4: Therapeutic Targets for TumorSemantic proximity Read ↗

Tumor suppressive role of the epigenetic master regulator BRD3 in colorectal cancerSemantic proximity Read ↗

Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in MitosisSemantic proximity Read ↗

BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinomaSemantic proximity Read ↗

BRD4 and Cancer: going beyond transcriptional regulationSemantic proximity Read ↗

Bromodomain containing 4 (BRD4) as a potential prognostic marker in a pan-cancer analysis of human tumorsSemantic proximity Read ↗

BRD4 Regulates Breast Cancer Dissemination through Jagged1/Notch1 SignalingSemantic proximity Read ↗

Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion.Semantic proximity Read ↗

BET proteins regulate homologous recombination‐mediated DNA repair: BRCAness and implications for cancer therapySemantic proximity Read ↗

BRD7 is a candidate tumour suppressor gene required for p53 function.Semantic proximity Read ↗

Oncogenic HJURP is driven by P53/ E2F1/FOXM1-axis regulated enhancer and potentiates TNBC proliferation and invasionSemantic proximity Read ↗

p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.