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BET proteins regulate homologous recombination‐mediated DNA repair: BRCAness and implications for cancer therapy

27 Sept 2018

Abstract excerpt

Bromodomain and Extra-Terminal (BET) proteins are historically involved in regulating gene expression and BRD4 was recently found to be involved in DNA damage regulation. Aims of our study were to assess BRD4 regulation in homologous recombination-mediated DNA repair and to explore novel clinical strategies through the combinations of the pharmacological induction of epigenetic BRCAness in BRCA1 wild-type triple...

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PMID: 30259975
DOI: 10.1002/ijc.31898

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