Back to search

Article

Oncogenic HJURP is driven by P53/ E2F1/FOXM1-axis regulated enhancer and potentiates TNBC proliferation and invasion

2023-01-19

Abstract excerpt

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor outcomes and lacks effective targeted therapies. We utilized the epigenomic landscape, TCGA database and clinical samples to show the activation of HJURP in TNBC, which is associated with poor prognosis, metastasis, and advanced stage. RNA-seq analysis of HJURP silencing induced malignant phenotypes-related transcription...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b0d37058-90cb-5d50-9b63-5ce75049872f
DOI
10.21203/rs.3.rs-2465454/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Oncogenic HJURP is driven by P53/ E2F1/FOXM1-axis regulated enhancer and potentiates TNBC proliferation and invasionDOI 10.21203/rs.3.rs-2465454/v1
Long non-coding RNA HUMT hypomethylation promotes lymphangiogenesis and metastasis via activating FOXK1 transcription in triple-negative breast cancerSemantic proximity
Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 <sup>+</sup> cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotypeSemantic proximity
p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator.Semantic proximity
Capturing the Variations in Mutant p53-Driven Regulatory Networks in Breast Cancer Subtypes, Its Clinical Relevance and a Novel Association With Androgen Receptor and EMT.Semantic proximity
Decoding gene regulatory circuitry underlying TNBC chemoresistance reveals biomarkers for therapy response and therapeutic targetsSemantic proximity
Cis-regulatory and long noncoding RNA alterations in breast cancer - current insights, biomarker utility, and the critical need for functional validation.Semantic proximity
Heterogeneity and transcriptional drivers of triple-negative breast cancerSemantic proximity
Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotypeSemantic proximity
A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancerSemantic proximity
In Vivo CRISPR Screens Identify RhoV as a Pro-Metastasis Factor of Triple-Negative Breast CancerSemantic proximity
Multifaceted roles of long non-coding RNAs in triple-negative breast cancer: biology and clinical applications.Semantic proximity
Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.Semantic proximity
Select a neighboring publication to make it the new centre.