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Article

BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma

1 Mar 2015

Abstract excerpt

Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that play an important role in chromatin remodeling and transcriptional regulation. In this study, we found that BRD4, a BET family member, is significantly upregulated in hepatocellular carcinoma (HCC) tissues compared with adjacent normal tissues. Furthermore, the overexpression of BRD4 in cancer tissues was correlated with poor...

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PMID: 25816404
DOI: 10.1177/0394632015572070

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