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Article

BRD7 is a candidate tumour suppressor gene required for p53 function.

Nature cell biology - 1 Apr 2010

Drost Jarno, Mantovani Fiamma, Tocco Francesca, Elkon Ran, Comel Anna, Holstege Henne, Kerkhoven Ron, Jonkers Jos, Voorhoeve P Mathijs, Agami Reuven, Del Sal Giannino

Abstract excerpt

Oncogene-induced senescence is a p53-dependent defence mechanism against uncontrolled proliferation. Consequently, many human tumours harbour p53 mutations and others show a dysfunctional p53 pathway, frequently by unknown mechanisms. Here we identify BRD7 (bromodomain-containing 7) as a protein...

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Source

Identifiers

PMID: 20228809
DOI: 10.1038/ncb2038

Genes

BRD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20228809-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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