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Article

Hydrophobic interactions within the C terminus pole helices tunnel regulate calcium-dependent inactivation of TRPC3 in a calmodulin-dependent manner.

Cell calcium - 1 Jan 2023

Wijerathne Tharaka, Lin Wei-Yin, Cooray Akila, Muallem Shmuel, Lee Kyu Pil

Abstract excerpt

Recent structural studies have shown that the carboxyl-terminus of many TRP channels, including TRPC3, are folded into a horizontal rib helix that is connected to the vertical pole helix, which play roles in inter-structural interactions and multimerization. In a previous work we identified I807 located in the pole helix with a role in regulation of TRPC3 by STIM1 (Lee et al., 2014, Liu et al., 2022). To further...

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Identifiers

PMID: 36495796
DOI: 10.1016/j.ceca.2022.102684
PMCID: PMC9875215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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