Article

Structural Mechanism of TRPC3 Channel Activation by the Moonwalker Mutation

2026-04-06

Abstract excerpt

TRPC3 is a calcium-permeable, non-selective cation channel that is activated by DAG. It is expressed in several tissues, especially in the cerebellum, and has been implicated in various human diseases. Despite recent progress in understanding the structural mechanism of TRPC3, how the channel opens remains elusive. Here, we present structures of hTRPC3 in an agonist-free resting state, determined using a DAG-bindi...

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Literature Corpus work: 0da87de5-c74b-598b-9b70-c75edf17dfbc
DOI: 10.64898/2026.04.03.716262

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