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Article

Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication.

Virologica Sinica - 1 Feb 2024

Ma Liping, Zheng Huabin, Ke Xianliang, Gui Rui, Yao Zhongzi, Xiong Jiasong, Chen Quanjiao

Abstract excerpt

Avian H9N2 viruses have wide host range among the influenza A viruses. However, knowledge of H9N2 mammalian adaptation is limited. To explore the molecular basis of the adaptation to mammals, we performed serial lung passaging of the H9N2 strain A/chicken/Hunan/8.27 YYGK3W3-OC/2018 (3W3) in mice and identified six mutations in the hemagglutinin (HA) and polymerase acidic (PA) proteins. Mutations L226Q, T511I, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37967718
DOI: 10.1016/j.virs.2023.11.004
PMCID: PMC10877434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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