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Article

Correlative assessment of p53 immunostaining patterns and TP53 mutation status by next-generation sequencing in lung adenocarcinoma (LUAD).

Histopathology - 1 Sept 2026

Zhang Yingying, Zheng Ke, Tang Yuan, Yang Ke, Chen Zihang, Li Yuli, Zhang Yajing, Zhang Guiping, Qiu Li, Peng Ran, Liu Xiaoyu, Jiang Lili

Abstract excerpt

OBJECTIVES: TP53 mutations, prevalent in 50%-70% of lung adenocarcinoma (LUAD), are associated with poor prognosis and therapeutic resistance. This study aimed to evaluate the diagnostic accuracy of p53 immunohistochemistry (IHC) as a rapid and cost-effective alternative to next-generation sequencing (NGS) for TP53 mutation detection in LUAD patients. MATERIALS AND METHODS: A multicentre cohort of 221 LUAD...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

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Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 42315496
DOI: 10.1111/his.70185
PMCID: PMC13441326

Genes

TP53
ERBB2
MET
MYC
PTCH1
RB1
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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